Gramma Isa was Cherokee she was on from the trail of tears and given to the Wood family.
Sources
family letter
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DNA Connections
It may be possible to confirm family relationships with Isa by comparing test results with other carriers of her mitochondrial DNA.
However, there are no known mtDNA test-takers in her direct maternal line.
It is likely that these autosomal DNA test-takers will share some percentage of DNA with Isa:
Her birth name is Rolls She had a brother Frank Rolls