Francis Wythens was born about 1635, son of William Wythens of Southend, gentleman of the privy chamber to Charles I, and his wife, Frances King. He was educated at St John's College, Oxford and Middle Temple, being called to the Bar in 1660, the year of the restoration of the monarchy in England.
In the interest of the Court he was returned to Parliament in 1679 as Member for Westminster in a vote that was apparently rigged and joined with George Jeffreys as an abhorrer, presenting a loyal address on 17 April 1680. He was knighted the following day.  The second exclusion parliament was strongly anti-court and Francis was called before it to explain his behaviour. According to Roger North instead of standing by what he had done and defending himself he apologised with the result that his election was declared void and Sir William Waller was seated in his place. This setback did not affect his career; he was appointed one of the Judges of the Court of the King's Bench. (1683-1687)
On 21 May 1685 he married Elizabeth Taylor, daughter of Sir ThomasTaylor, 1st Bt. The complete baronetage says she was Thomas's sister, not daughter  but it appears that that identification is wrong as Elizabeth would have been too old for her subsequent career had she been daughter of Thomas Taylor and his wife, Anne Hendley. Their daughter is represented by Elizabeth Taylor. Elizabeth bore him a daughter, Catherine, but the marriage was not a success and she became the mistress of Sir Thomas Colpeper, 3rd Baronet Colepeper.
In May 1685 Francis pronounced sentence on Titus Oates for perjury and in August accompanied George Jeffreys at the Bloody Assize held in the wake of Monmouth's rebellion. Despite his loyalty he was dismissed by James II in 1687. He fared no better under the new regime of William of Orange, having to appear before the Lords to explain his decision against Oates and was excluded by name from the indemnity bill.
Francis died 9 May 1704. 
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