Samuel was a staunch British Loyalist during the Revolution (although son Benjamin and son-in-law Nicholas Money fought for the Revolution) and he may have lost his land because of it. He moved from Maryland to Loudoun Co, VA for the last few years of his life.
It may be possible to confirm family relationships with Samuel by comparing test results with other carriers of his Y-chromosome or his mother's mitochondrial DNA.
However, there are no known yDNA or mtDNA test-takers in his direct paternal or maternal line.
It is likely that these autosomal DNA test-takers will share DNA with Samuel: