From 1900 US Census, Jefferson, Kanawha Co., WV:
"James H Keffer Head M 38 West Virginia
Allice Keffer Wife F 38 West Virginia
Lena M Keffer Daughter F 15 West Virginia
Glen Earl Keffer Son M 11 West Virginia
Jimmie M Keffer Son M 7 West Virginia"
From 1910 US Census, Smithfield, Roane Co., WV:
"James H Keffer Head M 46 West Virginia
Alice Keffer Wife F 48 West Virginia
James E Keffer Son M 17 West Virginia"
Sources
United States Census, 1900," database with images, FamilySearch (https://familysearch.org/ark:/61903/1:1:M9CG-YKF : accessed 25 October 2015), Lena M Keffer in household of James H Keffer, Jefferson district (Precincts 2-3) St. Albans town, Kanawha, West Virginia, United States; citing sheet 6A, family 120, NARA microfilm publication T623 (Washington, D.C.: National Archives and Records Administration, n.d.); FHL microfilm 1,241,762.
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DNA Connections
It may be possible to confirm family relationships with James by comparing test results with other carriers of his ancestors' Y-chromosome or mitochondrial DNA.
However, there are no known yDNA or mtDNA test-takers in his direct paternal or maternal line.
It is likely that these autosomal DNA test-takers will share some percentage of DNA with James: