Isaac married possibly 1828 in Alabama to Elizabeth Herring and second to Sarah Patton (documentation is needed). He was listed as a hotel keeper on the 1860 census. Possibly a daughter named Sarah.
1860 census, wife Sarah. Are these her children by Isaac?
Virginia 7
Linsen 3
Samuel 8/12
Sources
1840 census Pike Co., AL
1850 Census Pike Co., Al family 435/438
1860 Ramah P.O. District 2, Montgomery, Al
Need marriage records.
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DNA Connections
It may be possible to confirm family relationships with Isaac by comparing test results with other carriers of his Y-chromosome or his mother's mitochondrial DNA.
However, there are no known yDNA or mtDNA test-takers in his direct paternal or maternal line.
It is likely that these autosomal DNA test-takers will share some percentage of DNA with Isaac: