Elizabeth Holmes Singleton was born to James W Singleton and Judith Throckmorton Ball in Virginia. She married John Buford about 1835 in Hannibal, Marion County, Missouri, and they had issue. She passed in 1888.
Find a Grave, database and images (https://www.findagrave.com/memorial/34978474/elizabeth-holmes-buford: accessed 30 November 2023), memorial page for Elizabeth Holmes Singleton Buford (16 May 1816–13 Apr 1888), Find a Grave Memorial ID 34978474, citing Manchester Methodist Cemetery, Manchester, St. Louis County, Missouri, USA; Maintained by Susan Ing (contributor 47043987).
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Holmes-14953 and Singleton-5365 appear to represent the same person because: The dates, locations and FindAGrave match, along with spouse. Both children are listed in childrens names in census records. I believe Holmes was her middle name.