Epenetus Howe was born in Stamford, Connecticut about 1716. He married Mary Peck Mead on 7 Feb. 1739 in Stamford, Connecticut. They lived for a short time in Stamford and then moved to South Salem, Westchester, New York. Children: Epenetus, Isaac V, Mary, Esther, Ebenezer, Rachel, Gideon, Jesse, Sarah, David, Ireneus. He died on 16 Jan 1773 in South Salem, Westchester, New York.
They were admitted to the church in South Salem on 12 Jul 1752. Six of their children were baptized in South Salem on 12 Jul 1752.
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