Find A Grave, database and images (https://www.findagrave.com : accessed 16 October 2019), memorial page for John Ison (22 Apr 1778–1 Dec 1843), Find A Grave Memorial no. 168032534, citing Ison Cemetery, Lancaster, Garrard County, Kentucky, USA ; Maintained by linda masser (contributor 47781564)
"Kentucky, County Marriages, 1797-1954," database with images, FamilySearch (https://familysearch.org/ark:/61903/1:1:QKJS-8ZTZ : 17 May 2018), John Isom and Celey New, Oct 1797; citing Marriage, Washington, Kentucky, United States, various county clerks and county courts, Kentucky; FHL microfilm 241,382
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DNA Connections
It may be possible to confirm family relationships with John by comparing test results with other carriers of his Y-chromosome or his mother's mitochondrial DNA.
Y-chromosome DNA test-takers in his direct paternal line on WikiTree: