2nd Regiment, South Carolina Artillery was organized at Charleston, South Carolina, during the spring of 1862 using the 2nd South Carolina Artillery Battalion as its nucleus. Many of the men were recruited in the counties of Sumter, Darlington, and Charleston. It surrendered with the Army of Tennessee.
- Officers: Colonels A D Frederick and Thomas G Lamar, Lieutenant Colonel J Welsman Brown, and Major F F Warley.
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