Margaret was born about 1825. She passed away in 1892.
Sources
1860 US Census
1870 US Census
1880 US Census
findagrave.com
familysearch.org
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DNA Connections
It may be possible to confirm family relationships with Margaret by comparing test results with other carriers of her mitochondrial DNA.
However, there are no known mtDNA test-takers in her direct maternal line.
It is likely that these autosomal DNA test-takers will share some percentage of DNA with Margaret: