Goochland County, Virginia is a guess, based on the birth place of siblings
Sources
"Kentucky, County Marriages, 1797-1954," database with images, FamilySearch (https://familysearch.org/ark:/61903/1:1:FWRX-8JG : 17 May 2018), John Duncan and Asenth Lee, 18 Oct 1800; citing Marriage, , Pulaski, Kentucky, United States, district clerk, court clerk, county clerk and register offices from various counties; FHL microfilm 804,052.
Printout from John C. Campbell, Aug 1997, gives death date as 1816,also gives marriage place as Pulaski Co., Ky.
kueber.us
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DNA Connections
It may be possible to confirm family relationships with Esinthea by comparing test results with other carriers of her mitochondrial DNA.
However, there are no known mtDNA test-takers in her direct maternal line.
It is likely that these autosomal DNA test-takers will share some percentage of DNA with Esinthea: