Isaac was born about 1800. He was the son of Isaac Mead. He passed away in 1868.
Sources
"United States Census, 1850," database with images, FamilySearch (https://familysearch.org/pal:/MM9.1.1/MXQG-KH5 : 12 April 2016), Isaac Mead, York, Medina, Ohio, United States; citing family 1566, NARA microfilm publication M432 (Washington, D.C.: National Archives and Records Administration, n.d.).
"Michigan Deaths, 1867-1897," database with images, FamilySearch (https://familysearch.org/pal:/MM9.1.1/N3DN-146 : 12 December 2014), Isaac Mead, 08 Feb 1868; citing p 101 rn 59, Kalamo, Eaton, Michigan, Department of Vital Records, Lansing; FHL microfilm 2,363,447.
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DNA Connections
It may be possible to confirm family relationships with Isaac by comparing test results with other carriers of his ancestors' Y-chromosome or mitochondrial DNA.
Y-chromosome DNA test-takers in his direct paternal line on WikiTree: