Susan was born in 1840. She was the daughter of James Spivey and Mary Johnston. She passed away in 1918.
Sources
"United States Census, 1880," database with images, FamilySearch (https://familysearch.org/ark:/61903/1:1:MCCY-CMX : 15 August 2017), Susan Hamilton in entry for Randolph Hamilton, 1880; citing enumeration district ED 48, sheet 478B, NARA microfilm publication T9 (Washington D.C.: National Archives and Records Administration, n.d), roll 0421; FHL microfilm 1,254,421.
Ancestry tree. Identified via DNA search using multiple generations of descendants of John Hamilton. I plan to make a write up about it at some point.
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DNA Connections
It may be possible to confirm family relationships with Susan by comparing test results with other carriers of her mitochondrial DNA.
However, there are no known mtDNA test-takers in her direct maternal line.
It is likely that these autosomal DNA test-takers will share some percentage of DNA with Susan: