Francisco was born about 1788 to Manuel Angel de los Santos Torres and Maria Yginia Alvarez as estimated by the date of birth for his first child and the date of his marriage. He and his wife were godparents to María Dolores Esparza.
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"México, Jalisco, registros parroquiales, 1590-1979," database with images, FamilySearch (https://www.familysearch.org/ark:/61903/3:1:9392-PGW8?i=973&cc=1874591 : 5 Apr 2021), Yahualica > San Miguel > Bautismos 1810-1814 > image 974 of 1028; parroquias Católicas (Catholic Church parishes), Jalisco.
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DNA Connections
It may be possible to confirm family relationships with Francisco by comparing test results with other carriers of his Y-chromosome or his mother's mitochondrial DNA.
However, there are no known yDNA or mtDNA test-takers in his direct paternal or maternal line.
It is likely that these autosomal DNA test-takers will share some percentage of DNA with Francisco: