Alternate spelling: Lettis
Her first husband was John Lytle, Jr., the presumed father of Captain Thomas Lytle. John died in about 1772. She then married John Reed, a widower, whose deceased wife was Lettice sister-in-law, Martha Little.
Sources
Will dated 17 Feb 1807
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DNA Connections
It may be possible to confirm family relationships with Lettice by comparing test results with other carriers of her mitochondrial DNA.
However, there are no known mtDNA test-takers in her direct maternal line.
It is likely that these autosomal DNA test-takers will share some percentage of DNA with Lettice: