Allen, I see you've done DNA tests so I'm sure you've already covered this, but I have managed to work out a few transatlantic matches going back this far.
For example, I spotted that I had several matches on Ancestry who were descendants of Richard Rowe (and luckily there was a decent tree which said he was from Middle Rasen, Lincolnshire, where I also have ancestors). With that info it wasn't too difficult to go back a couple more generations and find our common ancestors, Robert Chatterton and Elizabeth Arnold, who married in 1750.
(I just managed to extend back the tree of another shared match to the same couple – will have to build some more profiles)
As Helen observed, an unusual surname really helps!