Timothy, the question, once one examines the language, is a tad confusing ... National (which nation?), ancestor (anyone's or only one's own?) and does one nominee have to be noted, a Notable, or can she be "just folks" ? .... hmm ... my own thinking was a female ancestor (American) from whom I am descended ... Joan of Arc is certainly a noted and Notable female of France -- although it is not known whether of a certainty she had no issue, none have been mentioned that I know of anyway -- but very often ancestor is used as a blanket word which includes siblings of our particular ancestor ...
My apologies if any are due ... Joan of Arc, believed to be childless and not a citizen of USA (still puzzling over which Nation) still qualifies or more accurately, given the way the question is worded, she cannot be excluded